Adding BioPerine® to the CalmLean® formula was a no-brainer for us. This clinically proven bioavailability enhancer helps increase nutritional uptake…This means… it has the potential to MULTIPLY the effectiveness of the formula overall… helping you achieve maximum results in minimum time. Best of all, BioPerine® is 100% natural, patented and clinically proven to be safe. In fact, it’s the ONLY patented compound of its kind shown to increase bioavailability by a whopping 30%. BioPerine® works as a thermogenic, “heating up” your metabolism like throwing gas on a blazing bonfire.